Array Manufacturing Processes
AMI’s business includes a wide range of custom capabilities to manufacture multiple unique formats of Point-of-Care devices, as well as standard processes for the production of arrays on glass slides and plates.
Each process has standard QC methods, and particular sampling plans or additional QC methods are implemented as required by customers.
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DI Water Rinse
Semiconductor spin-rinse-dry tools
Plasma Clean
Compatible with silicon, glass and plastic devices
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Vapor phase and liquid chemistries
- Control of density of functional surface groups
- Various levels of hydrophobicity/hydrophilicity
- Contact angle QC
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- Full automation capability
- Precision volume and concentration control
- Spotting buffers appropriate for maximum attachment
- Defined storage and thawing procedures
- Custom travelers for traceability
- Bar code labeling of plates
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Spotting Tool Features
- Non-contact piezo spotting
- 136 slides or 128 plates per spotting build
- Custom fixtures for semiconductor devices
- Spot volumes from picoliter to microliter range
- 100% automated optical inspection
- Intelligent chip feature-finding software for semiconductor devices
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Multiple chemistries available to stabilize capture probes for extended shelf life, and to minimize non-specific binding on array surfaces.
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AMI attaches a wide selection of formats of hybridization chambers, optimized for a range of assay chemistries and temperature cycles. Chambers are compatible with the Crocodile and all standard liquid handling systems
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Following deposition of capture probes, AMI has a set of capabilities to assemble custom assay chambers. Details of specific chambers are proprietary to our customers and are not shown here.
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QC Incoming Materials
- Slides
- Oligos
- Antibodies
- Chambers
Manufacturing QC
- Probe prep
- Spotting
- Post spotting
- Hyb chamber/cartridge assembly
Functional QC
- Proxy assay using standard or customer equipment
- Data transfer for product release
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Reagent Kit Production
- Custom kits to support customer assays
- Reagent preparation
- QC for concentration & purity
- Labeling
- Packaging
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Product Identification
- Laser-scribed ID, or bar code label, on each slide, microtiter plate or chip
- Storage in controlled environments
- Custom traveler for each product and manufacturing lot
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Packaging
- Custom moisture & anti-static bags
- N2 or vacuum seal
- Customer specific labeling
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